报告题目：Decoding the Protein Interaction Networks for Pluripotency and Reprogramming
报告人：WANG Jianlong， Associate Professor, Department of Developmental and Regenerative Biology，Black Family Stem Cell Institute, Mount Sinai School of Medicine（西奈山医学院）, New York, USA
时间：2015年7月27日（周一）下午3:00
地点：教学6号楼三层会议室（63312）
主持人：李相芝 教授

报告简介：
Molecular control of the pluripotent state in embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) resides in a core circuitry of master transcription factors Oct4, Sox2 and Nanog that together with other genetic and epigenetic factors form a core regulatory pluripotency network. The homeodomain transcription factor Nanog plays an important role in ESC self-renewal and is essential for acquiring ground state pluripotency during reprogramming. Enforced expression of Nanog liberates ESCs from requisite LIF dependence and reprograms “primed” pluripotent mouse EpiSCs to “naïve” pluripotent ESCs. Understanding how Nanog is transcriptionally regulated and how the Nanog protein orchestrates the genetic and epigenetic events in ESCs/iPSCs is important to further dissect mechanisms of ESC pluripotency and somatic cell reprogramming. I will summarize our studies employing both genomic and proteomic approaches to demonstrate the physical association and functional significance of Nanog with several novel transcriptional and epigenetic regulators in the maintenance and establishment of stem cell pluripotency. I will also present our most recent discovery of a novel pluripotency factor and its mechanistic action in controlling pluripotency and reprogramming.